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Tatsuhiko Kodama Selected Research

Hypoxia (Hypoxemia)

4/2014Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.
6/2013Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma.
5/2013Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.
8/2012Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.
1/2011Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.
10/2007Transcriptional activation by hypoxia and low-density lipoprotein loading in cultured vascular smooth muscle cells.
11/2005Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell.
10/2002Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions.

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Tatsuhiko Kodama Research Topics

Disease

42Neoplasms (Cancer)
02/2024 - 01/2002
17Inflammation (Inflammations)
01/2021 - 01/2002
14COVID-19
05/2024 - 01/2021
14Hepatocellular Carcinoma (Hepatoma)
12/2020 - 06/2002
8Type 2 Diabetes Mellitus (MODY)
11/2022 - 06/2006
8Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2021 - 12/2003
8Atherosclerosis
01/2019 - 01/2002
8Hypoxia (Hypoxemia)
04/2014 - 10/2002
7Carcinogenesis
11/2023 - 01/2002
7Hepatoblastoma
01/2018 - 10/2005
6Infections
11/2023 - 07/2004
6Body Weight (Weight, Body)
05/2015 - 12/2008
5Osteoporosis
03/2014 - 08/2005
4Cardiovascular Diseases (Cardiovascular Disease)
11/2022 - 01/2011
4Prostatic Neoplasms (Prostate Cancer)
07/2022 - 02/2012
4Down Syndrome (Down's Syndrome)
01/2021 - 11/2004
4Down Syndrome Critical Region
01/2021 - 11/2004
4Starvation
10/2019 - 12/2011
4Leukemia
01/2017 - 07/2007
4Neoplasm Metastasis (Metastasis)
01/2015 - 08/2013
4Bone Resorption
03/2014 - 03/2008
4Obesity
09/2010 - 12/2003
3Hypertriglyceridemia
11/2022 - 06/2006
3Non-alcoholic Fatty Liver Disease
11/2022 - 01/2020
3Atherosclerotic Plaque (Atheroma)
01/2021 - 02/2002
3Dyslipidemias (Dyslipidemia)
11/2019 - 01/2018
3Wilms Tumor (Wilm's Tumor)
01/2018 - 11/2006
3Arthritis (Polyarthritis)
01/2014 - 11/2006
3Renal Cell Carcinoma (Grawitz Tumor)
06/2013 - 01/2006
3Necrosis
11/2012 - 07/2010
3Insulin Resistance
03/2011 - 12/2003
3Melanoma (Melanoma, Malignant)
03/2010 - 11/2004
3Alzheimer Disease (Alzheimer's Disease)
10/2009 - 05/2005
3Liver Neoplasms (Liver Cancer)
04/2009 - 06/2006
3Diabetes Mellitus
02/2009 - 01/2003
3Amyloid Plaque
05/2007 - 09/2004
3Myocardial Infarction
04/2007 - 01/2004
2Kidney Neoplasms (Kidney Cancer)
06/2022 - 03/2015

Drug/Important Bio-Agent (IBA)

31Proteins (Proteins, Gene)FDA Link
02/2024 - 02/2003
11Immunoglobulin G (IgG)IBA
01/2023 - 01/2015
9Glucose (Dextrose)FDA LinkGeneric
01/2019 - 01/2003
9Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2010 - 09/2003
8PTX3 proteinIBA
01/2024 - 01/2007
8AntigensIBA
11/2023 - 12/2005
8AntibodiesIBA
11/2023 - 03/2002
8Messenger RNA (mRNA)IBA
11/2023 - 01/2002
8Triglycerides (Triacylglycerol)IBA
11/2022 - 06/2004
8LigandsIBA
01/2022 - 07/2007
8LipidsIBA
04/2016 - 10/2002
8GlypicansIBA
06/2009 - 02/2003
8oxidized low density lipoproteinIBA
12/2008 - 01/2002
7Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2020 - 10/2005
7Monoclonal AntibodiesIBA
03/2015 - 03/2005
6CholesterolIBA
11/2023 - 03/2003
6(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA
11/2022 - 11/2019
6Immunoglobulin M (IgM)IBA
05/2022 - 01/2021
6CalcineurinIBA
01/2021 - 11/2004
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2014 - 11/2004
5Neutralizing AntibodiesIBA
11/2023 - 01/2016
5HDL CholesterolIBA
11/2022 - 09/2010
5PPAR alphaIBA
01/2021 - 01/2006
5Insulin (Novolin)FDA Link
01/2019 - 01/2003
5Amyloid Precursor Protein Secretases (beta-Secretase)IBA
07/2010 - 09/2004
5Scavenger Receptors (Scavenger Receptor)IBA
04/2007 - 01/2002
5OligonucleotidesIBA
01/2007 - 01/2002
4ChromatinIBA
01/2022 - 08/2012
4Complement System Proteins (Complement)IBA
01/2021 - 06/2006
4RNA (Ribonucleic Acid)IBA
01/2018 - 12/2003
4Histone DemethylasesIBA
05/2013 - 08/2009
4CytokinesIBA
11/2012 - 10/2002
4C-Reactive ProteinIBA
01/2012 - 01/2004
4Biomarkers (Surrogate Marker)IBA
01/2012 - 04/2004
4alpha-Fetoproteins (alpha-Fetoprotein)IBA
04/2009 - 04/2004
4Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2007 - 01/2002
3VaccinesIBA
05/2024 - 03/2022
3Transcription Factors (Transcription Factor)IBA
11/2023 - 02/2006
3Androgen Receptors (Androgen Receptor)IBA
07/2022 - 02/2018
3Fenofibrate (CiL)FDA LinkGeneric
01/2020 - 08/2011
3Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
01/2020 - 07/2006
3Epidermal Growth Factor (EGF)IBA
01/2016 - 07/2007
3Histones (Histone)IBA
05/2015 - 01/2011
3Membrane Proteins (Integral Membrane Proteins)IBA
01/2015 - 01/2002
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2013 - 01/2002
3Hypoxia-Inducible Factor 1IBA
06/2013 - 12/2004
3Small Interfering RNA (siRNA)IBA
12/2011 - 01/2006
3Hepatocyte Nuclear FactorsIBA
02/2011 - 01/2008
3MucinsIBA
02/2011 - 05/2005
3Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
06/2009 - 12/2005
3Protein Isoforms (Isoforms)IBA
02/2009 - 10/2005
3LDL Lipoproteins (beta Lipoproteins)IBA
10/2007 - 01/2002
3DNA (Deoxyribonucleic Acid)IBA
07/2007 - 02/2004
3ThrombinFDA Link
07/2006 - 11/2004
2BNT162 VaccineIBA
01/2023 - 11/2022
2silicon phthalocyanineIBA
12/2022 - 01/2022
2kappa Opioid Receptors (kappa Opioid Receptor)IBA
07/2022 - 01/2022
2Immunoglobulin A (IgA)IBA
05/2022 - 02/2022
2Viral ProteinsIBA
02/2022 - 06/2021
2Nucleocapsid ProteinsIBA
02/2022 - 01/2021

Therapy/Procedure

14Therapeutics
02/2024 - 09/2003
3Castration
07/2022 - 02/2018